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Updated: Aug 14, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands
Joseph P Sabatucci1, Mark A Ashwell, Eugene Trybulski
1Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville PA 19426, USA. sabatuj@wyeth.com
Abstract:
The transcription factor nuclear factor-kappaB (NF-kappaB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-kappaB transcriptional activity but are devoid of conventional estrogenic activity.
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