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Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice

Christian Dürsteler1, Anna Mases, Victor Fernandez

  • 1Department of Anaesthesiology, Hospital Universitario del Mar, Universidad Autónoma de Barcelona, Paseo Marítimo 25, 08003 Barcelona, Spain.

European Journal of Pain (London, England)
|November 23, 2005
PubMed
Abstract

Insights

This study found that tramadol and anti-emetics like ondansetron and droperidol have an antagonistic interaction on pain relief and gastrointestinal transit in mice. This interaction varies depending on the pain stimulus, supporting previous clinical findings.

Area of Science:

  • Pharmacology
  • Pain Management
  • Gastrointestinal Physiology

Background:

  • Clinical evidence suggests ondansetron partially antagonizes tramadol-induced analgesia.
  • Understanding drug interactions is crucial for optimizing therapeutic outcomes and patient safety.

Purpose of the Study:

  • To investigate the interaction between tramadol and two anti-emetics (ondansetron and droperidol) on antinociception and gastrointestinal transit in mice.
  • To determine the nature of these interactions (e.g., additive, synergistic, antagonistic).

Main Methods:

  • Utilized acetic acid writhing and plantar tests to assess antinociceptive effects in female Swiss CD-1 mice.
  • Evaluated antitransit effects using a charcoal meal assay.
  • Employed isobolographic analysis and ANOVA to characterize drug interactions.

Main Results:

  • Both tramadol-ondansetron and tramadol-droperidol combinations showed antagonism in the writhing test.
  • Tramadol-ondansetron demonstrated antagonism in the plantar test, while tramadol-droperidol showed no significant interaction.
  • Both anti-emetics antagonized the gastrointestinal transit inhibitory effects of tramadol.

Conclusions:

  • The interaction between tramadol and anti-emetics on antinociception is stimulus-dependent, exhibiting antagonism or additive effects.
  • Both ondansetron and droperidol antagonize the anti-transit effects of tramadol.
  • These findings support previous clinical observations of antagonism between tramadol and these anti-emetics.

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