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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
Konstantin Arnold1, Lorenza Bordoli, Jürgen Kopp
1Biozentrum Basel, University of Basel Switzerland.
Bioinformatics (Oxford, England)
|November 23, 2005
Summary
The SWISS-MODEL workspace provides a web-based platform for protein structure homology modeling. This integrated service simplifies building protein models and analyzing biological experiments without software installation.
Area of Science:
- Biochemistry
- Structural Biology
- Bioinformatics
Background:
- Homology modeling is crucial for protein structure analysis when experimental data is unavailable.
- Building these models requires specialized software and up-to-date databases.
- Integrating these resources into a web-based workspace enhances accessibility.
Purpose of the Study:
- To introduce the SWISS-MODEL workspace, a comprehensive web-based service for protein homology modeling.
- To facilitate protein structure modeling for researchers without requiring extensive software installations.
Main Methods:
- The SWISS-MODEL workspace integrates necessary tools, programs, and databases for homology modeling.
- It offers a personal working environment for parallel modeling projects.
- Users can access updated protein sequence and structure databases within the workspace.
Main Results:
- The SWISS-MODEL workspace provides a user-friendly, integrated platform for homology modeling.
- It supports model building at various complexity levels with tools for template selection, model building, and quality evaluation.
- The service was demonstrated using human Cyclin A1 and human Transmembrane Protease 3 models.
Conclusions:
- The SWISS-MODEL workspace simplifies and enhances the process of protein structure homology modeling.
- Its web-based, integrated nature makes advanced modeling techniques accessible to a wider research community.
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