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Updated: Aug 14, 2026

Determination of Cardiac Output in a Porcine Model for Ex Vivo Pulmonary Perfusion
Published on: June 28, 2024
Cardiac output measurement using the transesophageal Doppler method is less accurate than the thermodilution method
Toshiyuki Sawai1, Toshihiro Nohmi, Yoshihiko Ohnishi
1Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan; Department of Anesthesia, National Cardiovascular Center, Suita, Japan.
Insights
Transesophageal Doppler and thermodilution methods for cardiac output (CO) measurement show agreement at 30 mmHg PaCO2. Thermodilution yields higher CO values at 40 mmHg PaCO2, impacting clinical accuracy.
Area of Science:
- Cardiovascular Physiology
- Anesthesiology
- Surgical Monitoring
Background:
- Cardiac output (CO) is a critical hemodynamic parameter.
- Transesophageal Doppler (TED) and thermodilution are common CO monitoring techniques.
- Partial arterial carbon dioxide (PaCO2) influences cerebral blood flow and potentially CO.
Purpose of the Study:
- To compare CO measurements by TED and thermodilution at different PaCO2 levels.
- To evaluate the impact of PaCO2 variations on the agreement between TED and thermodilution CO monitoring.
Main Methods:
- 30 patients undergoing off-pump coronary artery bypass graft surgery were studied.
- CO was measured using TED and thermodilution.
- PaCO2 was maintained at 30 mmHg and 40 mmHg in random order.
Main Results:
- Thermodilution showed significantly higher CO at 40 mmHg PaCO2 (4.17 L/min) vs. 30 mmHg PaCO2 (3.78 L/min).
- TED showed no significant difference in CO between 30 mmHg (3.77 L/min) and 40 mmHg PaCO2 (3.85 L/min).
- Bland-Altman analysis indicated agreement at 30 mmHg PaCO2 but a bias at 40 mmHg PaCO2.
Conclusions:
- TED and thermodilution methods for CO determination agree at 30 mmHg PaCO2.
- Thermodilution CO measurements are higher than TED at 40 mmHg PaCO2.
- PaCO2 levels can affect the agreement between these CO monitoring techniques.
Abstract:
Cardiac output (CO) determination using transesophageal Doppler is based on the measurement of descending aortic blood flow. Because cerebral blood flow is dependent on PaCO2, an increase in PaCO2 would result in an increase of CO because of the increase in cerebral blood flow and vice versa. We enrolled 30 patients undergoing off-pump coronary artery graft surgery in the study. The CO was determined by both transesophageal Doppler and thermodilution while PaCO2 was maintained at either 30 mmHg or 40 mmHg in random order. The CO by thermodilution was significantly higher at PaCO2 of 40 mmHg (4.17 +/- 0.94 L/min) than at 30 mmHg (3.78 +/- 0.85 L/min). On the other hand, there were no significant differences in CO by transesophageal Doppler: 3.85 +/- 0.76 L/min at PaCO2 of 40 mmHg and 3.77 +/- 0.74 at 30 mmHg. Bland-Altman analysis yielded bias and precision of -0.32 and 0.49 L/min at PaCO2 of 40 mmHg, and -0.01 and 0.34 L/min at 30 mmHg. These results indicate that both methods of CO measurement are in agreement at 30 mmHg of PaCO2, but the thermodilution method provides higher values at 40 mmHg of PaCO2.
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