Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do Surgical Residents Speak Up About Patient Safety Concerns? A National Survey Assessing Factors Associated With Resident Comfort Level in Raising Concerns to Supervising Physicians.

Journal of surgical education·2026
Same author

Management of Locoregional Melanoma.

Hematology/oncology clinics of North America·2025
Same author

Gene Expression Profile-Based Test to Predict Melanoma Sentinel Node Status: The MERLIN_001 Study.

JAMA surgery·2025
Same author

Quantum ghost imaging microscopy depth-of-field study.

Optics express·2025
Same author

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.

Neurophotonics·2025
Same author

The Landmark Series: Melanoma and Adjuvant Therapy.

Annals of surgical oncology·2025

Related Experiment Video

Updated: May 15, 2026

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling
08:21

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling

Published on: August 19, 2017

Autoimmune pancreatitis: unveiling a hidden entity.

Michael Wayne1, Keith A Delman, Tolga Kurt

  • 1The Center for Biliary and Pancreatic Surgery at Cabrini Medical Center, New York, NY 10003, USA. waynedocny@hotmail.com

Archives of Surgery (Chicago, Ill. : 1960)
|November 23, 2005
PubMed
Summary

Idiopathic chronic pancreatitis, often a diagnosis of exclusion, may be linked to lymphoplasmacytic sclerosing pancreatitis (LPSP) or autoimmune pancreatitis (AIP). This study highlights six cases where pathological examination revealed LPSP in patients initially diagnosed with idiopathic pancreatitis.

More Related Videos

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
05:51

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices

Published on: April 12, 2021

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Related Experiment Videos

Last Updated: May 15, 2026

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling
08:21

Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling

Published on: August 19, 2017

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
05:51

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices

Published on: April 12, 2021

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Area of Science:

  • Gastroenterology
  • Pathology
  • Immunology

Background:

  • Idiopathic chronic pancreatitis is a common form of calcifying pancreatitis when other causes are excluded.
  • Lymphoplasmacytic sclerosing pancreatitis (LPSP) and autoimmune pancreatitis (AIP) are increasingly recognized entities.
  • Distinguishing the etiology of chronic pancreatitis is crucial for appropriate management.

Observation:

  • This study reviewed six cases of patients with chronic recurrent pancreatitis.
  • All patients were referred for treatment of suspected autoimmune pancreatitis.
  • Postoperative pathological examination confirmed lymphoplasmacytic sclerosing pancreatitis in all six cases.

Findings:

  • The findings suggest a significant association between idiopathic chronic pancreatitis and lymphoplasmacytic sclerosing pancreatitis.
  • Pathological review revealed LPSP in all evaluated patients with chronic pancreatitis of unknown cause.
  • This indicates that LPSP may be an underdiagnosed cause of idiopathic chronic pancreatitis.

Implications:

  • Lymphoplasmacytic sclerosing pancreatitis should be considered more frequently in the differential diagnosis of chronic pancreatitis.
  • Accurate pathological diagnosis is essential for identifying LPSP as a cause of idiopathic chronic pancreatitis.
  • Considering LPSP may lead to improved diagnostic strategies and patient outcomes for chronic pancreatitis.