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Establishing normal reference ranges for PSA change with age in a population-based study: The Krimpen study
J L H R Bosch1, K Tilling, A M Bohnen
1Department of Urology, University Medical Centre Utrecht, Utrecht, The Netherlands. j.l.h.r.bosch@umcutrecht.nl
The Prostate
|November 23, 2005
Summary
This study establishes normal prostate-specific antigen (PSA) levels by age in men without prostate cancer. This provides a baseline to identify disease progression in active surveillance programs.
Area of Science:
- Urology
- Oncology
- Biostatistics
Background:
- Establishing normal prostate-specific antigen (PSA) levels is crucial for monitoring prostate cancer.
- Identifying disease progression in active surveillance programs requires a reliable baseline.
Purpose of the Study:
- To define the typical pattern of PSA change with age in men without prostate cancer.
- To create a predictive model for future PSA values based on age and PSA history.
- To establish a reference for detecting potential disease progression.
Main Methods:
- A community-based study collected PSA data at baseline and at 2.1 and 4.2 years.
- A bivariate multilevel growth curve model was employed to analyze PSA changes over time.
- The model estimated the relationship between PSA levels and age.
Main Results:
- PSA levels demonstrated a significant correlation with age alone.
- A predictive model was developed, allowing estimation of future PSA based on an individual's age and past PSA measurements.
- PSA doubling time calculations were integrated into the model for various age and PSA value combinations.
Conclusions:
- A method for establishing age-specific normal PSA levels using historical data from men without prostate cancer was developed.
- The model serves as a valuable tool for providing baseline data to detect disease progression in prostate cancer patients.
- This approach supports informed decision-making in active surveillance strategies.