Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Translational control by viral proteinases.

Richard E Lloyd1

  • 1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. rlloyd@bcm.tmc.edu

Virus Research
|November 24, 2005
PubMed
Summary

RNA viruses manipulate host cell translation for their own benefit. Viral proteinases, particularly in picornaviruses, not only process viral proteins but also control cellular translation machinery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CELF1 is a non-canonical eIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs.

Nucleic acids research·2026
Same author

Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study.

Scientific reports·2025
Same author

A case-cohort longitudinal study for the analysis of microbial associations and viruses on the risk of celiac disease (MAVRiC).

medRxiv : the preprint server for health sciences·2025
Same author

Temporal dynamics of the gut microbiome preceding celiac disease in genetically at-risk children.

medRxiv : the preprint server for health sciences·2025
Same author

Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study.

Diabetes care·2025
Same author

Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue.

Diabetologia·2025

Area of Science:

  • Virology
  • Molecular Biology
  • Biochemistry

Background:

  • RNA viruses often hijack host cell machinery for replication.
  • Viral proteinases play a crucial role in processing viral proteins and regulating host functions.
  • Picornaviruses are well-studied examples of viral proteinase-host translation interactions.

Purpose of the Study:

  • To explore the strategies RNA viruses use to regulate cellular translation.
  • To highlight the dual role of viral proteinases in polyprotein processing and translation control.
  • To discuss new findings on similar mechanisms in other viral systems.

Main Methods:

  • Literature review and synthesis of existing research on RNA virus translation.
  • Analysis of viral proteinase interactions with host translation factors.
  • Comparative discussion of mechanisms across different viral families.

Main Results:

  • Viral proteinases, especially in positive-strand RNA viruses, are key regulators of host translation.
  • Picornavirus proteinases exemplify the dual function of processing viral polyproteins and controlling cellular translation.
  • Emerging evidence indicates similar translation regulatory strategies in other RNA virus families.

Conclusions:

  • RNA viruses extensively modify host translation to favor viral gene expression.
  • Viral proteinases are critical effectors of this modulation, acting as both processing enzymes and translation regulators.
  • The study of these mechanisms provides insights into viral pathogenesis and potential therapeutic targets.

Related Experiment Videos