Inflammatory modulation of PPAR gamma expression and activity

Michelle B Crosby1, John Zhang, Tamara M Nowling

  • 1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
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Transducer Mechanism: Nuclear Receptors

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Co-activators and Co-repressors

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GPCRs Regulate Adenylyl Cylase Activity

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