Clinical comparison of three polyhexanide-preserved multi-purpose contact lens solutions

Area of Science:

• Ophthalmology
• Biomaterials Science
• Microbiology

Background:

• Polyhexanide (PHMB) is a common disinfectant in multi-purpose contact lens solutions.
• Different PHMB concentrations exist in commercially available systems.
• Contact lens wear is associated with risks of microbial keratitis and ocular surface disease.

Purpose of the Study:

• To compare the clinical performance of three PHMB-preserved contact lens disinfection systems with varying PHMB concentrations.
• To evaluate patient comfort, satisfaction, and corneal staining associated with each system.
• To assess differences in clinical outcomes between FDA group II and group IV disposable contact lenses.

Main Methods:

• A comparative clinical investigation was conducted.
• Participants used disposable contact lenses (FDA group II and group IV) with three different PHMB-preserved disinfection systems for one month.
• Patient-reported outcomes (comfort, satisfaction) and objective measures (corneal staining) were assessed at 14 and 28 days.

Main Results:

• The PHMB system with the highest concentration ('All-in-One') resulted in significantly lower insertion comfort (P<0.003) and overall satisfaction (P<0.05) compared to other systems.
• Corneal staining was significantly higher with the highest PHMB concentration product at both 14 days (P<0.001 for group II, P<0.02 for group IV) and 28 days (P<0.00001 for group II, P<0.03 for group IV).

Conclusions:

• Higher PHMB concentrations in multi-purpose solutions may negatively impact contact lens wearer comfort and increase the risk of corneal staining.
• Formulation differences in PHMB-preserved contact lens solutions can lead to varying clinical outcomes.
• Further research is warranted to optimize PHMB concentrations for safe and effective contact lens disinfection.