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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Infant sleeping environment and asthma at 7 years: a prospective cohort study

Leigh F Trevillian¹, Anne-Louise Ponsonby, Terence Dwyer

¹National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.

American Journal of Public Health

|November 24, 2005

Abstract

Objectives:

We investigated the role of infant bedding items, as part of a composite bedding environment, in the development of childhood wheezing.

Methods:

This prospective cohort investigation involved 863 children who participated in an infant survey in 1988 and an asthma study in Tasmania, Australia, in 1995. The derived 3 composite infant bedding categories corresponded to increasing numbers of house dust mite (HDM)-rich bedding items used. Outcomes measured included recent and frequent wheezing.

Results:

Composite infant bedding used was associated with recent wheezing. Effects increased at increasing levels of HDM-rich bedding items used. Effects were further enhanced by home environmental factors of bedroom heating, recent bedroom painting, and absence of bedroom carpeting. When any 2 or more of these environmental factors were present, a strong dose-response relationship was evident.

Conclusions:

Our results show that bedding exposures in infancy are prospectively associated with childhood wheezing and that home environmental conditions may modify this association.

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