Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pitfalls in estimating piperaquine elimination.

Joel Tarning1, Niklas Lindegårdh, Anna Annerberg

  • 1Department of Pharmacology, Göteborg University, Sweden.

Antimicrobial Agents and Chemotherapy
|November 24, 2005
PubMed
Summary

The antimalarial drug piperaquine has a terminal elimination half-life of 33 days in healthy volunteers, longer than previously thought. This highlights the need for extended sampling and sensitive assays for slowly eliminated drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety, tolerability and pharmacokinetic properties of intranasal artesunate in a first in human phase 1 trial.

Scientific reports·2026
Same author

Shared urinary metabolomic signatures as potential biomarkers for early intestinal <i>Schistosoma</i> infection across multiple species.

Current research in parasitology & vector-borne diseases·2026
Same author

Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Plasma and Intracellular Concentrations of Doxycycline and Azithromycin in Patients with Severe Scrub Typhus.

Antibiotics (Basel, Switzerland)·2026
Same author

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co-Infected With HIV.

Tropical medicine & international health : TM & IH·2026
Same author

Physiologically-Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach.

Clinical and translational science·2026

Area of Science:

  • Pharmacology
  • Drug Metabolism and Pharmacokinetics

Background:

  • Antimalarial drugs are crucial for global health.
  • Accurate pharmacokinetic data is essential for effective drug use.
  • Piperaquine is a key component of malaria treatment regimens.

Purpose of the Study:

  • To accurately determine the terminal elimination half-life of piperaquine.
  • To assess the impact of assay sensitivity and sampling duration on pharmacokinetic estimations.
  • To improve the understanding of piperaquine's disposition in vivo.

Main Methods:

  • Utilized a novel, highly sensitive assay.
  • Conducted extended blood sampling in a healthy volunteer.
  • Analyzed piperaquine concentrations over a prolonged period.

Related Experiment Videos

Main Results:

  • Estimated the terminal elimination half-life of piperaquine to be 33 days.
  • This value is significantly longer than previously reported estimates.
  • Demonstrated the influence of sensitive assays and extended sampling.

Conclusions:

  • Piperaquine is a slowly eliminated antimalarial drug.
  • Extended sampling duration and sensitive assay methodologies are critical for accurate pharmacokinetic characterization.
  • Findings have implications for malaria treatment guidelines and drug development.