Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic changes in malnutrition.

P W Emery1

  • 1Department of Nutrition and Dietetics, King's College London, London, UK. peter.emery@kcl.ac.uk

Eye (London, England)
|November 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review: the effect of prunes on gastrointestinal function.

Alimentary pharmacology & therapeutics·2014
Same author

The prevalence of PFS and prevalence and characteristics of reported food allergy; a survey of UK adults aged 18-75 incorporating a validated PFS diagnostic questionnaire.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2013
Same author

Faecal microbiota and short-chain fatty acids in patients receiving enteral nutrition with standard or fructo-oligosaccharides and fibre-enriched formulas.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2011
Same author

A review of the evidence for the impact of improving nutritional care on nutritional and clinical outcomes and cost.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2009
Same author

The effect of protein malnutrition on the capacity for protein synthesis during wound healing.

The journal of nutrition, health & aging·2009
Same author

Dietary counselling and food fortification in stable COPD: a randomised trial.

Thorax·2008

Malnutrition impairs the body's metabolic response to starvation and trauma. Adaptations include reduced metabolic rate and body size, but critical healing processes remain prioritized.

Area of Science:

  • Metabolic Adaptations
  • Nutritional Biochemistry

Background:

  • Malnutrition, defined as inadequate intake of major nutrients, affects diverse populations including children, adults in resource-limited settings, and patients with chronic diseases.
  • Co-existing infectious diseases complicate the assessment of metabolic and physiological changes in malnourished individuals.

Purpose of the Study:

  • To investigate the metabolic response to starvation and the impact of malnutrition on the body's adaptation to chronic underfeeding and trauma.
  • To elucidate the mechanisms underlying metabolic rate changes and substrate utilization during prolonged fasting and underfeeding.

Main Methods:

  • Review of metabolic responses to starvation, including changes in metabolic rate, gluconeogenesis, and ketone body utilization.
  • Analysis of adaptations to chronic energy deficiency, such as growth retardation and altered body composition.

Related Experiment Videos

  • Utilisation of an animal model to study the interaction between malnutrition and the metabolic response to surgical trauma, assessing energy expenditure and nitrogen excretion.

    • Main Results:

    • Starvation initially increases metabolic rate for gluconeogenesis, later suppressed to conserve muscle protein, with ketones becoming the primary brain fuel.
    • Chronic underfeeding leads to reduced basal metabolic rate per cell and adaptations like slow growth and smaller adult body size.
    • Malnourished rats exhibited attenuated energy expenditure and nitrogen excretion post-surgery, indicating impaired substrate mobilization for inflammatory responses, though muscle healing remained prioritized.

    Conclusions:

    • Malnutrition significantly alters metabolic responses to starvation and trauma, impairing substrate mobilization for critical processes like inflammation and repair.
    • The body adapts to chronic energy deficiency through reduced growth and metabolic rate, prioritizing essential functions like muscle healing.
    • Understanding these complex metabolic adaptations is crucial for managing malnutrition and its consequences in various clinical settings.