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Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates

Eric J Fechter1, Bogdan Olenyuk, Peter B Dervan

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|November 25, 2005
PubMed
Summary

New fluorescent DNA-binding polyamides offer a novel method for genetic sequence detection. These molecules specifically bind and fluoresce upon encountering target double-stranded DNA, eliminating the need for denaturation.

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