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Related Experiment Videos

Low-dose vitamin K to augment anticoagulation control.

Alicia M Reese1, Lisa E Farnett, Roger M Lyons

  • 1College of Pharmacy, University of Texas, Austin, and the Anticagulation Clinics of North America, San Antonio, Texas, USA. a.reese@usip.edu

Pharmacotherapy
|November 25, 2005
PubMed
Summary

Daily low-dose vitamin K supplements stabilized international normalized ratios (INRs) in warfarin patients. This vitamin K therapy reduced INR fluctuations and improved time in therapeutic range.

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Area of Science:

  • Pharmacology
  • Hematology
  • Clinical Medicine

Background:

  • Warfarin therapy requires careful monitoring of International Normalized Ratios (INRs) to prevent bleeding or clotting.
  • Fluctuating INRs in patients on warfarin can be challenging to manage, even without identifiable causes.
  • Vitamin K plays a crucial role in the coagulation cascade and warfarin metabolism.

Purpose of the Study:

  • To evaluate the efficacy of daily low-dose oral vitamin K supplementation in reducing INR variability.
  • To assess the impact of vitamin K on maintaining INRs within the therapeutic range for warfarin patients.

Main Methods:

  • Retrospective analysis of INR data from patients on warfarin with fluctuating INRs.
  • Inclusion of eight patients receiving daily oral vitamin K supplementation (starting at 100 microg/day).

Related Experiment Videos

  • Monitoring of INR responses by anticoagulation providers.

    • Main Results:

    • Daily vitamin K supplementation significantly decreased INR standard deviation (p<0.05).
    • The percentage of INRs within 0.2 units of the target range increased from 32% to 57% (76% relative increase).
    • Time in therapeutic INR range also showed a significant improvement.

    Conclusions:

    • Low-dose oral vitamin K supplementation effectively reduced INR fluctuations in selected warfarin patients.
    • Vitamin K therapy improved the stability and time in therapeutic range of INRs.
    • This intervention offers a potential strategy for managing difficult-to-control INRs in warfarin therapy.