Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium in renal failure patients.

K Milly1, L Wit, C Diskin

  • 1Department of Zoology and Wildlife Science, Auburn University, Ala. 36830.

Nephron
|January 1, 1992
PubMed
Summary

This study found normal blood selenium (Se) concentrations in patients with chronic kidney disease, indicating no deficiency. Serum Se levels were consistently lower than plasma Se levels across all groups.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modification of Proteins by Metabolites in Immunity.

Immunity·2020
Same author

SOCS3 revisited: a broad regulator of disease, now ready for therapeutic use?

Cellular and molecular life sciences : CMLS·2016
Same author

Pilot study on the effect of hyperimmune egg protein on elevated cholesterol levels and cardiovascular risk factors.

Journal of medicinal food·2009
Same author

Differential response to low-fat diet between low and normal HDL-cholesterol subjects.

Journal of lipid research·2000
Same author

Prevention of hydrolytic rancidity in rice bran during storage.

Journal of agricultural and food chemistry·1999
Same author

Low-dose T(3) improves the bed rest model of simulated weightlessness in men and women.

The American journal of physiology·1999

Area of Science:

  • Clinical Chemistry
  • Trace Element Metabolism
  • Nephrology

Background:

  • Selenium (Se) is an essential trace element crucial for various physiological functions.
  • Altered trace element status is common in patients with chronic kidney disease (CKD).
  • Understanding Se levels in CKD is important for nutritional management.

Purpose of the Study:

  • To determine blood Se concentrations in healthy individuals and patients with varying stages of CKD.
  • To investigate the relationship between Se levels and Se carriers in these populations.
  • To assess the need for Se supplementation in CKD patients.

Main Methods:

  • Quantified Se concentrations in plasma, serum, and whole blood using atomic absorption spectrophotometry.
  • Analyzed 29 healthy controls, 19 non-dialyzed CKD patients, and 10 dialyzed end-stage renal disease patients.
  • Correlated Se levels with alpha 2-globulin concentrations.

Main Results:

  • No significant differences in blood Se concentrations were observed between CKD patients and healthy controls.
  • Total Se concentrations did not correlate with most Se carriers, except for alpha 2-globulin.
  • Serum Se concentrations were significantly lower than plasma Se concentrations across all groups (p < 0.0001).
  • Se levels remained stable during dialysis in end-stage renal disease patients.

Conclusions:

  • Patients with chronic kidney disease, including those on dialysis, exhibit normal blood Se concentrations.
  • Se supplementation is not indicated for these patient groups based on current Se levels.
  • Serum and plasma Se concentrations should not be used interchangeably due to significant differences.

Related Experiment Videos