Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mathematical modelling and controlled drug delivery: matrix systems.

Mario Grassi1, Gabriele Grassi

  • 1Department of Chemical Engineering (DICAMP) University of Trieste, Piazzale Europa 1, Trieste, I-34127, Italy. mariog@dicamp.univ.trieste.it

Current Drug Delivery
|November 25, 2005
PubMed
Summary

This study reviews physical and mathematical models for drug release from matrix systems. Understanding drug release kinetics, including swelling, erosion, and diffusion, is crucial for controlled drug delivery advancements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.

The Lancet. Neurology·2026
Same author

Long-term effects of multisession gamma transcranial alternating current stimulation in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Corrigendum to "Towards a universal size distribution in a polymer network. Implications for drug delivery and plasmonic nanoparticle transport phenomena in polysaccharide and synthetic hydrogels" [Int. J. Biol. Macromol. 317 (2025), 144741].

International journal of biological macromolecules·2026
Same author

Mucoactive Agents in Muco-Obstructive Lung Diseases: A Critical Reappraisal of Pharmacological Effects and Clinical Outcomes.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Pilot Study on the Use of Rheology and Low Field Nmr to Characterize the Liver of Obese Patients Undergoing Metabolic and Bariatric Surgery.

International journal of molecular sciences·2026
Same author

Cumulative Incidence in Monogenic Alzheimer's Disease and Frontotemporal Dementia: Gene-Gene Interaction Effect.

International journal of molecular sciences·2026

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Matrix systems are integral to controlled drug delivery.
  • Mathematical modeling provides a framework for understanding drug release.
  • Drug release kinetics are influenced by numerous physical and chemical factors.

Purpose of the Study:

  • To provide a comprehensive review of physical and mathematical modeling for drug release from matrix systems.
  • To analyze the key factors governing drug release kinetics.
  • To discuss various modeling approaches, from empirical to theoretical.

Main Methods:

  • Analysis of matrix structure and topology.
  • Examination of drug release mechanisms (swelling, erosion, dissolution, diffusion).

Related Experiment Videos

  • Review of empirical, semi-empirical, and theoretical mathematical models.

    • Main Results:

    • Detailed discussion of factors influencing drug release kinetics.
    • Comparison of different modeling approaches for accuracy and applicability.
    • Study of release kinetics from polydispersed spherical particles.

    Conclusions:

    • Current understanding of drug release from matrix systems is robust from both physical and modeling perspectives.
    • Further refinements in modeling are continuously sought.
    • Accurate modeling is essential for optimizing controlled drug delivery systems.