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Selenium derivatives as cancer preventive agents.

Tarek Aboul-Fadl1

  • 1Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Egypt. fadl@aun.edu.eg

Current Medicinal Chemistry. Anti-Cancer Agents
|November 25, 2005
PubMed
Summary

Selenium plays a crucial role in cancer prevention, primarily through its antioxidant enzyme functions. Selenium derivatives show promise as chemopreventive agents, moving beyond nutritional supplementation for cancer treatment.

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Area of Science:

  • Biochemistry
  • Oncology
  • Nutritional Science

Background:

  • Selenium's role in cancer prevention is increasingly recognized, supported by laboratory, clinical, and epidemiological evidence.
  • Its primary mechanism involves the function of selenium within antioxidant enzyme systems.

Purpose of the Study:

  • To review recent advancements in the application of selenium derivatives for cancer chemoprevention.
  • To highlight the shift of selenium supplementation from nutritional support to pharmacological intervention in cancer care.

Main Methods:

  • Review of laboratory experiments.
  • Analysis of clinical trials.
  • Evaluation of epidemiological data.
  • Examination of animal studies and intervention trials.

Main Results:

  • Selenium derivatives demonstrate efficacy in preventing specific cancers.
  • These compounds exhibit antitumorigenic effects during the post-initiation phases of cancer development.
  • Significant interest exists in synthesizing novel selenium-containing compounds for chemoprevention.

Conclusions:

  • Selenium is a vital element in cancer chemoprevention strategies.
  • Selenium derivatives offer a promising avenue for pharmacological intervention against cancer.
  • Further research into selenium-containing compounds is warranted for their development as cancer preventive agents.

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