Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug tissue distribution: study methods and therapeutic implications.

J M Lanao1, M A Fraile

  • 1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Spain. jmlanao@usal.es

Current Pharmaceutical Design
|November 25, 2005
PubMed
Summary

Understanding drug tissue distribution is crucial for predicting treatment effectiveness. This review compares methods, highlighting non-invasive techniques and advanced pharmacokinetic models for optimized drug delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population pharmacokinetics of albendazole in patients with neurocysticercosis.

International journal of clinical pharmacology and therapeutics·2009
Same author

Influence of clinical diagnosis in the population pharmacokinetics of amikacin in intensive care unit patients.

Clinical drug investigation·2008
Same author

Time-dependent pharmacokinetics of cyclosporine (Neoral) in de novo renal transplant patients.

Journal of clinical pharmacy and therapeutics·2005
Same author

Neuropharmacokinetic characterization of lamotrigine after its acute administration to rats.

Methods and findings in experimental and clinical pharmacology·2005
Same author

Population pharmacokinetics of high dose ibuprofen in cystic fibrosis.

Archives of disease in childhood·2003
Same author

Population pharmacokinetics of digoxin in pediatric patients.

Therapeutic drug monitoring·2002

Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Drug Development

Background:

  • Predicting tissue drug concentrations and responses from plasma levels is challenging.
  • Methodological and ethical limitations exist for direct human tissue studies.
  • Optimizing drug delivery requires deeper understanding of tissue distribution.

Purpose of the Study:

  • To compare existing and novel methods for studying drug tissue distribution.
  • To review advancements in pharmacokinetic and pharmacodynamic modeling for tissue distribution.
  • To explore the therapeutic implications of drug tissue distribution.

Main Methods:

  • Comparative analysis of various tissue distribution study methods.
  • Focus on non-invasive techniques like positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (NMR).

Related Experiment Videos

  • Review of evolving pharmacokinetic analysis strategies, including compartment, physiological, spatial, fractal, and pharmacokinetic-pharmacodynamic models.

    • Main Results:

    • Non-invasive imaging techniques offer new avenues for human tissue distribution research.
    • Advanced pharmacokinetic models provide more accurate analysis of drug distribution.
    • Model-independent analyses using mean transit times and deconvolution are viable alternatives.
    • In silico models are valuable tools in drug discovery and development.

    Conclusions:

    • Improved understanding of drug tissue distribution aids in designing targeted drug delivery systems.
    • Enhanced drug selectivity can be achieved through prodrugs and carrier systems.
    • Tissue distribution significantly impacts therapeutic outcomes, particularly in areas like antiretroviral and gene therapy.