Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triclosan-bacteria interactions: single or multiple target sites?

M Gomez Escalada1, A D Russell, J-Y Maillard

  • 1Welsh School of Pharmacy, Cardiff University, UK.

Letters in Applied Microbiology
|November 25, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enterococcus spp. ability to form a dry surface biofilm: a route to persistence on environmental surfaces.

The Journal of hospital infection·2025
Same author

Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant.

The Journal of hospital infection·2025
Same author

Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy.

The Journal of hospital infection·2024
Same author

Evaluating the antimicrobial efficacy of long-lasting hand sanitizers on skin.

The Journal of hospital infection·2023
Same author

MiniBooNE and MicroBooNE Combined Fit to a 3+1 Sterile Neutrino Scenario.

Physical review letters·2022
Same author

Dry surface biofilms: what you need to know.

British journal of hospital medicine (London, England : 2005)·2022

Triclosan inhibits bacterial growth at low concentrations and is bactericidal at higher concentrations, impacting all growth phases. Its lethal mechanism is complex, not solely explained by metabolic pathway inhibition.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance
  • Biochemistry

Background:

  • Triclosan is a widely used antimicrobial agent.
  • Understanding its effects on microbial growth dynamics is crucial.

Purpose of the Study:

  • To investigate the inhibitory and lethal effects of triclosan on microorganisms.
  • To determine these effects across different microbial growth phases.

Main Methods:

  • Minimum inhibitory concentrations (MICs) were determined using standard broth and agar methods.
  • Bacterial growth kinetics were analyzed using the Bioscreen C microbial growth analyzer.
  • Efficacy across growth phases was assessed via a standard suspension test.

Main Results:

Related Experiment Videos

  • Triclosan increased the lag phase duration in a concentration-dependent manner.
  • Bacterial population growth kinetics were altered by triclosan exposure.
  • Higher triclosan concentrations were bactericidal irrespective of growth phase, though stationary and washed cells showed more resilience.

    • Conclusions:

    • Low triclosan concentrations inhibit bacterial growth, while high concentrations are bactericidal across all growth phases.
    • Triclosan's lethal interaction with bacterial cells is complex and may involve metabolic pathway inhibition.