Increased granulocyte chemotactic protein-2 concentrations in peritoneal fluid of women with endometriosis
Nobuhiro Suzumori1, Xaio Xi Zhao, Kaoru Suzumori
1Department of Obstetrics & Gynecology, Nagoya City University Graduate School of Medicine, 1-Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan. og.n.suz@med.nagoya-cu.ac.jp
Background:
To evaluate the release of granulocyte chemotactic protein-2 (GCP-2) into peritoneal fluid in women with endometriosis, we measured its concentration with reference to the disease stage and the phase of the menstrual cycle.
Methods:
Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 64 women with endometriosis (n = 38) or cystadenomas (n = 26). GCP-2 concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay.
Result:
Our findings indicated elevated concentrations of GCP-2 in peritoneal fluid from women with endometriosis during the proliferative phase, which were positively correlated with the stage of endometriosis.
Conclusion:
Inflammation associated with endometriosis may be involved in the pathogenesis of the disease through increasing levels of peritoneal fluid GCP-2.
