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[Effects of short-term chemotherapy on the compliance of rabbit abdominal aorta]
1Sixth Hospital of Shanghai Jiaotong University, Shanghai 200233, China.
Objective:
To investigate the effect of short-term chemotherapy on the compliance of rabbit abdominal aorta, and understand the changes in the biomechanical properties of the blood vessels after chemotherapy.
Methods:
Fifteen rabbits were divided into 5 groups, 4 of which were subjected to injection with chemotherapeutic agents for 5 days to evaluate the compliance of the abdominal aorta at 2, 7, 14, and 21 days after the therapy with the other group without chemotherapy serving as the control.
Results:
The compliance of the abdominal aorta was obviously decreased after chemotherapy and reached the lowest level 14 days after short-term chemotherapy, suggesting that the drugs resulted in vascular injury enough to alter the biomechanical properties of the blood vessels.
Conclusion:
Short-term chemotherapy can decrease the compliance of the blood vessels, which may deteriorate with time but such changes can be reversible.
