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Related Experiment Videos

Brainstem auditory function at term in preterm babies with and without perinatal complications.

Ze D Jiang1, Dorothea M Brosi, Zhi Hau Li

  • 1Children's Hospital, Fudan University, Shanghai, China. zedong.jiang@paediatrics.ox.ac.uk

Pediatric Research
|November 25, 2005
PubMed
Summary

Preterm infants with perinatal complications show impaired auditory brainstem function, particularly in central pathways. This risk of central auditory impairment is evident in their brainstem auditory evoked response results.

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Neonatal Medicine

Background:

  • Premature birth (30-36 weeks gestation) can impact neurodevelopment.
  • Auditory brainstem function is crucial for processing sound information.
  • Perinatal complications may exacerbate developmental challenges in preterm infants.

Purpose of the Study:

  • To assess the functional integrity of the auditory brainstem in preterm infants at term.
  • To investigate the effects of perinatal complications on auditory brainstem responses.
  • To identify potential risks for central auditory impairment in this population.

Main Methods:

  • Utilized maximum length sequence brainstem auditory evoked response (MLS BAER) testing.
  • Evaluated auditory brainstem responses in preterm infants (30-36 weeks gestation) at term.

Related Experiment Videos

  • Compared responses between preterm infants with and without perinatal complications.

    • Main Results:

    • Preterm infants with perinatal complications exhibited increased wave V latency and I-V, III-V intervals, especially at higher click rates (455/s, 910/s).
    • Significant reductions in waves III and V amplitudes were observed in complicated preterm infants.
    • Preterm infants without complications showed minimal MLS BAER abnormalities, primarily a slight III-V interval increase.

    Conclusions:

    • Preterm infants with perinatal complications demonstrate impaired auditory brainstem function, particularly in central auditory pathways.
    • These impairments are more pronounced at higher stimulus rates.
    • Preterm infants with perinatal complications are at high risk for central auditory impairment.