Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

29.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
29.9K
Overview of Cell Signaling01:23

Overview of Cell Signaling

16.6K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
16.6K
Bacterial Translocation and Protein Secretion01:26

Bacterial Translocation and Protein Secretion

1.2K
Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...
1.2K
Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

1.7K
Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
1.7K
Global Regulatory Systems01:28

Global Regulatory Systems

965
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
965
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

81
Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
81

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enzyme agglomerates change cytoplasmic fluidity.

Molecular cell·2026
Same author

Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast.

Science advances·2026
Same author

Western diet suppresses canonical intestinal stem cells and reprograms c-Kit⁺ reserve stem cells via proinflammatory dysbiosis.

bioRxiv : the preprint server for biology·2026
Same author

Toolbox of FRET-based c-di-GMP biosensors and its FRET-To-Sort application for genome-wide mapping of c-di-GMP regulation.

Nature communications·2026
Same author

Effects of multiple cell regulators on curli gene expression in <i>Escherichia coli</i>.

Journal of bacteriology·2025
Same author

Diclofenac and acetaminophen dim the acute-phase response but amplify expression of the iron regulator hepcidin in liver cancer cells.

Cell systems·2025

Related Experiment Video

Updated: May 6, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

46.1K

Design principles of a bacterial signalling network.

Markus Kollmann1, Linda Løvdok, Kilian Bartholomé

  • 1Institut für Physik, Universität Freiburg, Hermann-Herder-Str. 3, D-79104 Freiburg, Germany. markus.kollmann@fdm.uni-freiburg.de

Nature
|November 25, 2005
PubMed
Summary

Bacterial chemotaxis networks evolve robust designs to function despite noisy cellular environments. The E. coli chemotaxis pathway is optimally structured for accurate responses, conserving resources and ensuring consistent performance across populations.

More Related Videos

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
12:24

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

15.6K
Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
08:51

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling

Published on: June 25, 2015

8.7K

Related Experiment Videos

Last Updated: May 6, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

46.1K
DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
12:24

DNA-affinity-purified Chip DAP-chip Method to Determine Gene Targets for Bacterial Two component Regulatory Systems

Published on: July 21, 2014

15.6K
Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
08:51

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling

Published on: June 25, 2015

8.7K

Area of Science:

  • * Molecular Biology
  • * Systems Biology
  • * Biophysics

Background:

  • * Cellular biochemical networks operate in noisy environments with imperfect components.
  • * Gene regulation and signal transduction networks require high output precision.
  • * Evolved network structures often exhibit inherent robustness against perturbations.

Purpose of the Study:

  • * Investigate the optimal design of bacterial chemotaxis signaling networks.
  • * Quantify the robustness of different pathway topologies to gene expression noise.
  • * Analyze the evolutionary adaptations for robustness in biological signaling.

Main Methods:

  • * Combined theoretical analysis and experimental investigations.
  • * Experimentally determined intercellular variations in chemotaxis protein expression.
  • * Employed computer simulations to assess pathway robustness.

Main Results:

  • * Identified E. coli's chemotaxis network as the most robust among tested topologies.
  • * Demonstrated that this network structure allows accurate chemotactic response for most individuals.
  • * Showcased the pathway's efficiency in minimizing resource costs via optimized protein expression.

Conclusions:

  • * Bacterial chemotaxis pathways have evolved optimal designs for robust performance.
  • * Topological principles compensating for intercellular variations are conserved in bacterial chemosensory systems.
  • * The E. coli chemotaxis network balances performance with resource efficiency.