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Effects of iEW synthetic peptide isomers on bone marrow colony-forming capacity in vivo
O V Semina1, T N Semenets, I A Zamulaeva
1Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. ovs45@mail.ru
Abstract:
Studies of cooperative effects of D- or L-isomers of iEW dipeptide and neuraminidase on the number of splenic CFU, comparison of the peptide effects on CD34+ cells and splenic CFU, and evaluation of the effects of iEW D- or L-isomers on parameters of T-cell activation showed that interactions of L-(iEW) and D-(iEW) with CD34+ surface receptors are realized through the same mechanism, while their different biological effects on hemopoietic precursor cells in vivo can be explained by their different influence on T-component of the microenvironment.