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Vitamin D and psoriasis.

K E Lowe¹, A W Norman

¹Department of Biochemistry, University of California, Riverside 92521.

Nutrition Reviews

|May 1, 1992

Summary

This summary is machine-generated.

The skin produces vitamin D (1,25-(OH)2D3) from sunlight exposure. This vitamin D hormone may effectively treat psoriasis by interacting with its nuclear receptor in skin cells.

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Area of Science:

Dermatology
Endocrinology
Biochemistry

Background:

The skin synthesizes vitamin D (1,25-(OH)2D3) via cutaneous 7-dehydrocholesterol conversion upon sun exposure.
The skin functions as a target organ for the active hormonal form of vitamin D, 1,25-(OH)2D3.

Purpose of the Study:

To investigate the role of vitamin D and its receptor in skin.
To explore the potential therapeutic applications of 1,25-(OH)2D3 analogs in dermatological conditions, specifically psoriasis.

Main Methods:

Analysis of nuclear receptors for 1,25-(OH)2D3 in human skin samples.
Examination of 1,25-(OH)2D3 nuclear receptors in cultured human skin keratinocytes.

Main Results:

The nuclear receptor for 1,25-(OH)2D3 was identified in both human skin samples and cultured skin keratinocytes.

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Emerging data suggest that 1,25-(OH)2D3 or its analogs show promise for treating certain types of psoriasis.

Conclusions:

The skin possesses the necessary machinery to both produce and respond to vitamin D.
Vitamin D analogs represent a potential novel therapeutic strategy for managing psoriasis.