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Related Experiment Videos

Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.

M Tiberio1, D T Chard, D R Altmann

  • 1NMR Research Group, Institute of Neurology, Queen Square, London, UK.

Journal of Neurology
|November 25, 2005
PubMed
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In early multiple sclerosis (MS), reduced brain metabolites like N-acetyl-aspartate (NAA) in normal-appearing white matter (NAWM) and grey matter (CGM) may partially recover over time, suggesting potential reversibility of early neuronal damage.

Area of Science:

  • Neuroimaging
  • Biochemistry
  • Neurology

Background:

  • Multiple Sclerosis (MS) is characterized by neuronal and axonal damage, indicated by reduced N-acetyl-aspartate (NAA) in brain tissues.
  • Metabolite changes in MS, including myoinositol (Ins), creatine (Cr), choline (Cho), and glutamate plus glutamine (Glx), are known but their temporal dynamics are unclear.

Purpose of the Study:

  • To investigate the longitudinal changes in brain metabolite concentrations in early relapsing-remitting MS (RRMS).
  • To characterize metabolite profiles in normal-appearing white matter (NAWM) and cortical grey matter (CGM) in early RRMS.
  • To explore the relationship between metabolite changes and clinical outcomes in RRMS.

Main Methods:

  • Proton magnetic resonance spectroscopic imaging ((1)H-MRSI) was performed annually for two years on 20 RRMS patients and 10 healthy controls.

Related Experiment Videos

  • LCModel was used to quantify concentrations of total NAA (tNAA), Cr, Cho, Ins, and Glx in NAWM and CGM.
  • Statistical analyses compared metabolite levels between groups and over time.

    • Main Results:

    • Baseline tNAA was significantly reduced in the NAWM (-7%) and CGM (-8.7%) of MS patients compared to controls.
    • NAWM tNAA concentrations showed a trend towards recovery from baseline in MS patients.
    • No other significant longitudinal changes in metabolite profiles were observed in MS subjects or between MS and control groups.

    Conclusions:

    • Early neuronal and axonal damage in MS, reflected by reduced tNAA, may be partly reversible.
    • Serial (1)H-MRSI may be less sensitive to progressive pathological changes in early RRMS compared to other MRI techniques.
    • Further research is needed to understand the long-term implications of these metabolite dynamics in MS progression.