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Related Experiment Videos

Xanthoma of the urinary bladder.

C F Lindboe1

  • 1Department of Pathology, Sørlandet sykehus HF, N-4604, Kristiansand, Norway. christian.fredrik.lindboe@sshf.no

International Urology and Nephrology
|November 25, 2005
PubMed
Summary

Urinary bladder xanthomas are rare, reactive lesions appearing as yellow-white plaques. These lipid-laden macrophage accumulations can mimic tumors, necessitating careful diagnosis to differentiate from neoplastic processes.

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Area of Science:

  • Uropathology
  • Oncology
  • Dermatology

Background:

  • Xanthomas are rare, reactive lesions characterized by lipid-laden macrophages.
  • Urinary bladder xanthomas present as yellow-white mucosal plaques, potentially mimicking neoplastic conditions.
  • These lesions are often associated with underlying inflammatory or metabolic conditions.

Observation:

  • A case of a 78-year-old woman with a tumor-suspect xanthoma of the urinary bladder is presented.
  • The xanthoma occurred subsequent to multiple resections of non-invasive bladder carcinomas.
  • Clinical presentation included yellow-white mucosal plaques suspicious for malignancy.

Findings:

  • Biopsy revealed stromal accumulation of lipid macrophages.
  • No significant inflammatory component was observed in the lesional tissue.
  • Histopathological analysis confirmed the diagnosis of xanthoma, excluding a neoplastic etiology.

Implications:

  • Accurate histopathological diagnosis is crucial to distinguish xanthomas from bladder tumors.
  • Understanding the reactive nature of xanthomas aids in appropriate patient management.
  • Further research into the specific triggers and pathogenesis of urinary bladder xanthomas is warranted.

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