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Acute postinfectious crescentic glomerulonephritis: clinicopathologic presentation and risk factors

Amr A El-Husseini1, Hussein A Sheashaa, Alaa A Sabry

  • 1Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt. amr_2000_2002@yahoo.com

International Urology and Nephrology
|November 25, 2005
PubMed

Insights

Postinfectious crescentic glomerulonephritis (CGN) is severe, often causing rapid kidney failure. Persistent hypertension and nephrotic proteinuria during follow-up predict poor renal outcomes in these patients.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Glomerular crescent formation signifies severe glomerulonephritis.
  • Postinfectious glomerulonephritis with crescents typically has a better prognosis, but poorer outcomes are reported in South Africa.
  • This study investigates prognostic factors in postinfectious crescentic glomerulonephritis (CGN).

Purpose of the Study:

  • To determine the presentation patterns of postinfectious CGN.
  • To identify prognostic factors influencing renal and patient outcomes in postinfectious CGN.

Main Methods:

  • Retrospective analysis of 23 postinfectious CGN cases managed between 1990-2000.
  • Evaluation of clinical, laboratory, and histopathological data.
  • Mean follow-up of 40.1 months.

Main Results:

  • Univariate analysis identified age, hypertension, and nephrotic range proteinuria as risk factors for renal dysfunction.
  • Multivariate analysis confirmed hypertension and nephrotic range proteinuria as significant risk factors.
  • Hypertension and elevated serum creatinine at follow-up impacted patient mortality.

Conclusions:

  • Postinfectious CGN is a severe condition presenting with rapid renal failure.
  • Persistent hypertension and nephrotic range proteinuria are key predictors of poor renal outcomes.
Abstract

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