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Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
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Uncover genetic interactions in Caenorhabditis elegans by RNA interference

Angelo Fortunato1, Andrew G Fraser

  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Cambridge, Hinxton, UK. af4@sanger.ac.uk

Bioscience Reports
|November 25, 2005
PubMed

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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