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Congenital herpetic keratitis.

D S Hutchison, R E Smith, P B Haughton

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Congenital herpetic keratitis, an advanced corneal inflammation caused by Herpes simplex virus type 1, was diagnosed in a newborn. This case suggests in utero acquisition, marking the first report of this condition.

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    Area of Science:

    • Ophthalmology
    • Virology
    • Neonatology

    Background:

    • Herpes simplex virus (HSV) infections can affect newborns, but congenital presentation is rare.
    • Ocular involvement in neonatal HSV typically occurs postnatally.
    • Advanced epithelial and stromal keratitis at birth suggests prenatal acquisition.

    Purpose of the Study:

    • To report the first case of congenital herpetic keratitis.
    • To highlight the possibility of in utero transmission of Herpes simplex virus type 1 to the cornea.

    Main Methods:

    • Clinical observation of a newborn infant with bilateral keratitis.
    • Viral culture from corneal scrapings and skin vesicles.
    • Identification of Herpes simplex virus type 1.

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    Main Results:

    • An infant presented with advanced epithelial and stromal keratitis at birth.
    • Herpes simplex virus type 1 was isolated from the cornea and subsequent skin lesions.
    • The severity of keratitis indicated prenatal infection.

    Conclusions:

    • This case represents the first documented instance of congenital herpetic keratitis.
    • In utero transmission of HSV-1 can cause severe ocular disease in neonates.
    • Early diagnosis and management are crucial for affected infants.