Related Experiment Video

Updated: Aug 14, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Proteomics of TGF-beta signaling and its impact on breast cancer

Serhiy Souchelnytskyi1

  • 1Uppsala University, Ludwig Institute for Cancer Research, Box 595, SE-75124, Uppsala, Sweden. serhiy.souchelnytskyi@licr.uu.se

Expert Review of Proteomics
|November 26, 2005
PubMed

Insights

Large-scale proteomics studies reveal complex cancer mechanisms. Understanding transforming growth factor-beta (TGF-beta) signaling in breast cancer advances novel therapeutic strategies.

Area of Science:

  • Oncology and Molecular Biology
  • Proteomics and Cancer Signaling

Background:

  • Cancer progression involves complex molecular mechanisms, necessitating large-scale studies like proteomics.
  • Transforming growth factor-beta (TGF-beta) exhibits dual roles in cancer, inhibiting early tumor growth but promoting later-stage metastasis.

Purpose of the Study:

  • To review recent advances in proteomics studies of TGF-beta signaling in breast cancer.
  • To elucidate the contribution of TGF-beta signaling to breast tumorigenesis and treatment.

Main Methods:

  • Utilizing proteomics to monitor thousands of proteins simultaneously.
  • Analyzing TGF-beta-dependent regulation of key cellular processes including proliferation, apoptosis, DNA repair, and transcription.

Main Results:

  • Proteomics has significantly expanded the understanding of TGF-beta's role in breast cancer.
  • Identified novel signaling mechanisms contributing to tumorigenesis.

Conclusions:

  • Enhanced understanding of TGF-beta signaling pathways in breast cancer.
  • Opens avenues for developing novel anticancer treatments and drugs targeting TGF-beta pathways.

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