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Published on: October 12, 2017

Dyslipidaemia and cardiovascular risk in HIV infection

Ranjababu Kulasekaram1, Barry S Peters, Anthony S Wierzbicki

  • 1HIV Medicine, St. Thomas' Hospital, London, UK. ranjababu.kulasegaram@gstt.nhs.uk

Current Medical Research and Opinion
|November 26, 2005
PubMed

Insights

Human immunodeficiency virus (HIV) infection and its treatment, particularly protease inhibitors, can cause dyslipidemia. This increases cardiovascular disease risk, alongside other factors in HIV/AIDS patients.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) is a growing concern in human immunodeficiency virus (HIV) patients on highly active antiretroviral therapy (HAART).
  • Dyslipidemia is common in HIV infection and associated with protease inhibitor (PI) antiretroviral drugs.
  • Atherosclerotic disease and diabetes, linked to lipodystrophy, are major causes of morbidity in HIV/acquired immunodeficiency syndrome (AIDS).

Purpose of the Study:

  • To review lipid changes in HIV infection and HAART.
  • To contextualize these lipid changes with other cardiac risk factors in HIV.
  • To explore other causes of CVD in HIV-infected individuals.

Main Methods:

  • Multi-database keyword search.
  • Literature review and synthesis of findings.

Main Results:

  • HIV infection and HAART contribute to dyslipidemia.
  • Lipid abnormalities are associated with increased atherosclerotic disease and diabetes risk.
  • Lipodystrophy is a significant factor in CVD morbidity in HIV/AIDS.

Conclusions:

  • Lipid changes are a critical consideration in managing cardiovascular risk in HIV patients.
  • Comprehensive assessment of all CVD risk factors is essential for HIV-infected individuals.
  • Further research is needed to fully understand and mitigate CVD in the context of HIV.

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