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Macular capillary hemodynamic changes associated with Raynaud's phenomenon.

B D Salmenson¹, J Reisman, S H Sinclair

¹Department of Ophthalmology, Hahnemann University, Philadelphia, PA 19102.

|June 1, 1992

Summary

Raynaud's phenomenon significantly reduces retinal capillary blood flow, potentially causing retinal injury. This flow reduction persists even after rewarming, indicating prolonged vasoconstriction in severe cases.

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Area of Science:

Ophthalmology
Vascular Biology
Rheumatology

Background:

Raynaud's phenomenon involves episodic digital arteriolar spasms.
Previous research suggests potential links between Raynaud's and ocular circulation changes.
This study investigates macular retinal capillary hemodynamics in Raynaud's patients.

Purpose of the Study:

To assess macular retinal capillary hemodynamics in patients with Raynaud's phenomenon.
To determine if ocular circulation is affected by the vasospastic episodes characteristic of Raynaud's.

Main Methods:

Utilized the blue field entoptic simulation technique.
Measured retinal capillary density and velocity in 42 volunteers (18 with secondary Raynaud's, 8 with connective tissue disease, 16 healthy controls).

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Measurements were taken before, during, and after hand immersion in ice water.

Main Results:

Severe Raynaud's patients showed a 30% decrease in retinal capillary flow during cold exposure (P<0.05).
Flow remained 17% reduced for at least 10 minutes post-immersion (P<0.05).
No significant flow reduction was observed in control groups.

Conclusions:

Prolonged retinal capillary flow reduction in Raynaud's is likely due to arteriolar vasoconstriction.
This ocular vasoconstriction mirrors findings in other systemic vascular beds.
Recurrent retinal ischemia may lead to visual dysfunction or damage.