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Published on: December 22, 2016
Onchocerciasis-related epilepsy? Prospects at a time of uncertainty
Benoît Marin1, Michel Boussinesq, Michel Druet-Cabanac
1Institut de Neuroépidémiologie et de Neurologie Tropicale (EA 3174), Faculté de Médecine, 2 rue de Docteur Marcland, 87025 Limoges Cedex, France.
Abstract:
Epilepsy and onchocerciasis (river blindness) constitute serious public health problems in several tropical countries. There are four main mechanisms that might explain a relationship between these two diseases: (i) the presence of Onchocerca volvulus in the central nervous system; (ii) the pathogenicity of various O. volvulus strains; (iii) immunological mechanisms involving cross-reactive immunization or cytokine production during infection; and (iv) the triggering role of insomnia due to itching.
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