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Related Experiment Videos

Reversible splenial lesion in clinically mild encephalitis.

I B Yeh1, L C S Tan, Y Y Sitoh

  • 1Department of Diagnostic Imaging, National University Hospital, Singapore 119074. berneyeh@gmail.com

Singapore Medical Journal
|November 26, 2005
PubMed
Summary

Mild encephalitis with reversible central splenium of the corpus callosum (SCC) lesions is a newly identified condition. This case report highlights a young man with seizures and SCC lesions that fully resolved, emphasizing a favorable prognosis and conservative management.

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Encephalitis is a brain inflammation with diverse causes and presentations.
  • The central splenium of the corpus callosum (SCC) is a specific brain region.
  • A recently described entity involves mild encephalitis with reversible SCC lesions.

Observation:

  • A 20-year-old male presented with fever and generalized seizures.
  • Initial MRI revealed a characteristic lesion in the SCC.
  • The lesion demonstrated T1/T2 signal prolongation, restricted diffusion, and decreased ADC values.

Findings:

  • Follow-up MRI after three months showed complete resolution of the SCC lesion.
  • The patient experienced a mild clinical course and achieved a full recovery.

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  • This supports the reversible nature of the clinicoradiological findings.

    • Implications:

    • This entity, encephalitis with reversible SCC lesions, appears to have an excellent prognosis.
    • Recognition of this condition can help avoid unnecessary invasive investigations and treatments.
    • Understanding differential diagnoses is crucial for appropriate patient management.