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Microinfusion using hollow microneedles.

Wijaya Martanto1, Jason S Moore, Osama Kashlan

  • 1School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Pharmaceutical Research
|November 26, 2005
PubMed
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Optimizing hollow microneedle drug delivery requires understanding flow dynamics. Partial retraction of microneedles significantly enhances fluid microinfusion rates into the skin by overcoming dermal tissue resistance.

Area of Science:

  • Biomedical Engineering
  • Dermal Drug Delivery
  • Microneedle Technology

Background:

  • Microneedle technology offers potential for transdermal drug delivery.
  • Understanding flow dynamics through hollow microneedles is crucial for optimizing infusion protocols.

Purpose of the Study:

  • To investigate the impact of experimental parameters on microinfusion through hollow microneedles.
  • To optimize drug delivery protocols and identify barriers to flow in dermal microinfusion.

Main Methods:

  • Glass microneedles were inserted into human cadaver skin to infuse a sulforhodamine solution.
  • Flow rates were measured as a function of insertion depth, retraction, infusion pressure, tip geometry, and hyaluronidase presence.

Main Results:

Related Experiment Videos

  • Single microneedles achieved flow rates of 15-96 microl/h.
  • Partial microneedle retraction increased flow up to 11.6-fold, reaching 1130 microl/h with optimized parameters.
  • Flow resistance from compressed dermal tissue was identified as a key barrier.

Conclusions:

  • Partial microneedle retraction and methods to overcome dermal resistance enable therapeutically relevant microinfusion rates.
  • Optimized protocols for hollow microneedles can enhance transdermal drug delivery.