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Updated: Aug 14, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

The molecular basis of prostate cancer

A Yvonne Olsson1, Colin S Cooper

  • 1Institute of Cancer Research, Male Urological Cancer Research Centre, Sutton, Surrey SM2 5NG.

British Journal of Hospital Medicine (London, England : 2005)
|November 29, 2005
PubMed

Insights

Prostate cancer develops due to accumulating genetic changes. Key pathways controlling cell division, DNA repair, and cell death are altered, driving cancer progression.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cancer is characterized by the accumulation of genetic alterations.
  • Prostate cancer development is a complex process involving multiple genetic changes.

Purpose of the Study:

  • To review the critical genetic alterations in key cellular pathways involved in prostate cancer.
  • To highlight the role of these alterations in prostate cancer pathogenesis.

Main Methods:

  • Literature review of genetic alterations in prostate cancer.
  • Analysis of key cellular control pathways including cell division, development, DNA repair, angiogenesis, and cell death.

Main Results:

  • Identified significant alterations in cell division regulatory pathways.
  • Highlighted disruptions in DNA repair mechanisms contributing to genomic instability.
  • Reviewed changes in angiogenesis and programmed cell death pathways crucial for tumor growth and survival.

Conclusions:

  • Genetic alterations in cell division, DNA repair, angiogenesis, and cell death are fundamental to prostate cancer development.
  • Understanding these pathway alterations provides insights into potential therapeutic targets for prostate cancer.

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