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[Experimental study on action of acupoint embedding thread on ANCA in the rat of ulcerative colitis]
Yang Zou1, Zhu-Liang Zou, Xiao-Fang Yang
1Provincial Center for Clinical Laboratory, Guizhou Provincial People's Hospital, Guiyang 550002, China. DXL@public.GZ.cn
Objective:
To observe therapeutic effect of acupoint embedding thread therapy on ulcerative colitis and to study the mechanism.
Methods:
The rat model of ulcerative colitis was developed with 2,4-dinitrochlorobenzene method. The 20th day after the end of model development, they were randomly divided into a model group, a salicylazosulfapyridine (SASP) treatment group and an acupoint embedding thread therapy group. The SASP treatment group were treated with intragastrical perfusion of 4.5% SASP suspension, and the acupoint embedding thread therapy group were treated with embedding thread at "Zusanli" (ST 36) and "Shangjuxu" (ST 37). Anti-neutrophil cytoplasmic antibody (ANCA) was detected with indirect immunofluorescence, and the pathological changes were investigated with pathological tissue section technique.
Results:
The positive rate of ANCA reached to 62.5% in the rat with ulcerative colitis with significant differences among the 3 groups. After treatment, the positive rate of ANCA was decreased in the two treatment groups (P < 0.05, P < 0.01).
Conclusion:
Acupoint embedding thread therapy has definite therapeutic effect on ulcerative colitis and the mechanism is possibly related with the decrease of ANCA.
