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Updated: Aug 14, 2026

Probing Myosin Ensemble Mechanics in Actin Filament Bundles Using Optical Tweezers
Published on: May 4, 2022
Mathematical modeling of the myosin light chain kinase activation
Ales Fajmut1, Marko Jagodic, Milan Brumen
1Department of Physics, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia. ales.fajmut@uni-mb.si
Abstract:
The mathematical model presented here describes the interactions among Ca2+, calmodulin (CaM), and myosin light chain kinase (MLCK) and consists of a kinetic scheme taking into account 7 reactions instead of 12 as proposed previously. We derive a system of 5 nonlinear ordinary differential equations. Solving it yields the prediction of active MLCK as a function of [Ca2+] whereby the active MLCK is defined to be proportional to the Ca4CaM.MLCK complex concentration. The model predictions are compared with other theoretical and experimental predictions of active MLCK as well as with the results of our previously proposed complex model.
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