Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood clot dissolution dynamics simulation during thrombolytic therapy.

Igor Sersa1, Gregor Tratar, Ales Blinc

  • 1JoZef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.

Journal of Chemical Information and Modeling
|November 29, 2005
PubMed
Summary

Fast blood flow accelerates clot dissolution by increasing agent transport and surface forces. A new model links dissolution rate to flow forces and velocity, validated by magnetic resonance imaging data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An international, multispecialty consensus document on the optimal management of patients with internal carotid artery occlusion.

Journal of vascular surgery·2026
Same author

The Influence of Evaluator Experience, Dynamic Versus Static Ultrasound Image Interpretation, and Probe Frequency on Fascicle Differentiation.

The Journal of hand surgery·2026
Same author

Is altered hemodynamics the main culprit for failure of covered stents?

VASA. Zeitschrift fur Gefasskrankheiten·2026
Same author

Optimal treatment of preclinical cardiovascular disease: A narrative review with a focus on carotid artery stenosis.

Seminars in vascular surgery·2026
Same author

Advanced Magnetic Resonance Methods in Materials Chemistry Analysis.

Molecules (Basel, Switzerland)·2026
Same author

The Role of High-Sensitivity Cardiac Troponin and Ischemia-Modified Albumin in Patients with Lower Extremity Peripheral Arterial Disease.

International journal of molecular sciences·2025

Area of Science:

  • Biophysics
  • Hematology
  • Medical Imaging

Background:

  • Nonocclusive blood clots form channels with vessel walls, leading to high-velocity blood flow.
  • Fast blood flow enhances clot dissolution, a phenomenon requiring theoretical explanation.

Purpose of the Study:

  • To develop a theoretical model explaining the accelerated dissolution of blood clots in flowing blood.
  • To quantify the relationship between blood flow dynamics and clot dissolution rates.

Main Methods:

  • Proposed a mathematical model where clot dissolution rate is proportional to blood flow forces and velocity.
  • Validated the model using experimental data from magnetic resonance imaging (MRI) of clots.
  • Utilized dynamical magnetic resonance microscopy to observe clot dissolution in an artificial blood flow system.

Related Experiment Videos

Main Results:

  • The model successfully explains the increased clot dissolution rate observed with fast blood flow.
  • Experimental data from MRI confirmed the model's predictions regarding clot dissolution dynamics.
  • Identified increased transport of dissolution agents and mechanical forces as key factors.

Conclusions:

  • The developed model provides a theoretical basis for enhanced clot dissolution in flowing blood.
  • Blood flow dynamics, specifically forces and velocity, are critical determinants of clot lysis rates.
  • This research offers insights into thrombolysis mechanisms and may inform therapeutic strategies.