Related Experiment Video
Updated: Aug 8, 2026
07:13
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
Abnormal regional left ventricular mechanics in treated hypertensive patients with 'normal left ventricular function'
Han B Xiao1, Shahla Kaleem, Carolyn McCarthy
1Department of Cardiology, Ealing Hospital, Uxbridge Road, Middlesex UB1 3HW, UK. hanbinxiao@hotmail.com
International Journal of Cardiology
|November 29, 2005
Summary
Controlled hypertension patients often have normal global heart function but subtle regional issues. Echocardiography reveals reduced longitudinal systolic excursion and impaired early relaxation in these patients, indicating mechanical inefficiency.
Area of Science:
- Cardiology
- Echocardiography
- Hypertension Research
Background:
- Global systolic and diastolic left ventricular (LV) function is often normal in controlled hypertension.
- Left ventricular hypertrophy (LVH) may be present without apparent global dysfunction.
- Regional myocardial function in hypertensive patients requires further investigation.
Purpose of the Study:
- To assess regional myocardial mechanics in patients with controlled hypertension.
- To determine if conventional echocardiography can detect subtle LV dysfunction.
- To investigate differences in LV regional mechanics between hypertensive patients and controls.
Main Methods:
- Employed long-axis M-mode echocardiography to evaluate 26 hypertensive patients and 10 controls.
- Assessed LV regional mechanics, including longitudinal systolic excursion and early relaxation.
- Compared echocardiographic parameters between hypertensive patients and age-matched controls.
Main Results:
- Hypertensive patients showed significantly reduced longitudinal systolic excursion in the LV free wall and septum.
- Impaired early relaxation and atrial contraction were observed in the LV free wall of hypertensive patients.
- Conventional global LV function and diastolic function did not differ significantly between groups.
Conclusions:
- Conventional echocardiography may not detect subtle LV mechanical inefficiency in controlled hypertension.
- Assessment of regional mechanics offers a sensitive method for detecting LV dysfunction in hypertensive patients.
- Regional mechanical assessment is crucial for evaluating LV function in controlled hypertension with LVH.
More Related Videos
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
08:57Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Related Concept Videos
01:17Pathophysiology of Heart Failure
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
01:20Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:25Aortic Regurgitation III: Medical Management
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...