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Related Experiment Videos

Chromosomal inversion discovered in C3H/HeJ mice.

Ellen C Akeson1, Leah Rae Donahue, Wesley G Beamer

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Genomics
|November 29, 2005
PubMed
Summary

The C3H/HeJ mouse strain has a chromosomal inversion on Chromosome 6, named In(6)1J. This genetic variation prevents recombination in a significant portion of Chr 6, impacting genetic studies.

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Area of Science:

  • Genetics
  • Genomics
  • Mouse Models

Background:

  • The C3H/HeJ inbred mouse strain is widely used in genetic research.
  • Understanding chromosomal variations is crucial for accurate genetic analysis.

Purpose of the Study:

  • To identify and characterize a specific chromosomal inversion in C3H/HeJ mice.
  • To inform researchers about the implications of this inversion for genetic studies.

Main Methods:

  • Analysis of the C3H/HeJ mouse genome.
  • Identification of structural variations, specifically chromosomal inversions.

Main Results:

  • C3H/HeJ mice are homozygous for a chromosomal inversion on Chromosome 6.
  • The inversion, designated In(6)1J, spans approximately 73 Mb to 116 Mb (about 20% of Chr 6).

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  • No recombination occurs in this region during linkage crosses using C3H/HeJ mice.

    • Conclusions:

    • The In(6)1J inversion does not affect the phenotype of C3H/HeJ mice.
    • Researchers should consider In(6)1J when using C3H/HeJ mice for genetic mapping on Chromosome 6.
    • Avoid using C3H/HeJ mice for genetic analysis in the inverted region or interpret results cautiously.