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Related Experiment Videos

Increased EMMPRIN (CD 147) expression during oral carcinogenesis.

Nadarajah Vigneswaran1, Simone Beckers, Sabine Waigel

  • 1Department of Diagnostic Sciences, The University of Texas Health Science Center at Houston, Dental Branch, 6516 M.D. Anderson Blvd., Room 3.094G, Houston, TX 77030, USA. Nadarajah.Vigneswaran@UTH.TMC.EDU

Experimental and Molecular Pathology
|November 29, 2005
PubMed
Summary

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Extracellular matrix metalloproteinase inducer (EMMPRIN) is significantly upregulated in oral premalignant and oral squamous cell carcinoma cells. This early overexpression suggests EMMPRIN contributes to oral cancer development.

Area of Science:

  • Oral oncology
  • Cancer biology
  • Biochemistry

Background:

  • Oral premalignant (OPM) lesions and oral squamous cell carcinoma (OSCC) represent a spectrum of oral cancer development.
  • Understanding molecular changes during oral carcinogenesis is crucial for early detection and treatment.
  • Extracellular matrix metalloproteinase inducer (EMMPRIN) is a cell surface glycoprotein implicated in cancer progression.

Purpose of the Study:

  • To investigate EMMPRIN expression patterns in normal oral epithelium, OPM lesions, and OSCC.
  • To determine the role of EMMPRIN in the early stages of oral carcinogenesis.

Main Methods:

  • Gene expression profiling (microarray analysis)
  • Quantitative real-time PCR (qRT-PCR)
  • Western blotting

Related Experiment Videos

  • Immunohistochemistry
  • Organotypic culture models
  • Analysis of cell lines and tissue specimens

    • Main Results:

    • EMMPRIN expression was markedly upregulated in OPM and OSCC cells compared to normal oral epithelial cells.
    • EMMPRIN showed increased expression in dysplastic leukoplakias, correlating with dysplasia grade.
    • Strong cell surface expression of EMMPRIN was observed in primary and metastatic OSCC.
    • EMMPRIN was detected in high and low glycosylated forms and released by OSCC cells.

    Conclusions:

    • EMMPRIN overexpression occurs early in oral carcinogenesis, even in premalignant stages.
    • EMMPRIN likely plays a contributing role in the tumorigenesis of oral squamous cell carcinoma.
    • EMMPRIN may serve as a potential biomarker for early oral cancer detection.