Related Experiment Video
Updated: Aug 14, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities
Silvia Schenone1, Chiara Brullo, Olga Bruno
1Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3-16132 Genoa, Italy. schensil@unige.it
Abstract:
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Drugs for Treatment of Ulcerative Colitis in IBD
Antihypertensive Drugs: Thiazide-Class Diuretics