Related Experiment Video
Updated: Aug 11, 2026

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Life before the pre-B cell receptor checkpoint: specification and commitment of primitive lymphoid progenitors in
Rosana Pelayo1, Robert S Welner, Yoshinori Nagai
1Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA.
Abstract:
The production of B cells is a complex process determined by well-timed combinations of intrinsic factors and environmental cues that guide the differentiation of primitive progenitors in the bone marrow. Expression of several key transcription factors and receptor-stromal cell ligand interactions are landmarks of the earliest events in B lymphopoiesis in adult bone marrow. We describe this as a gradual loss of options for other blood cell lineages coincident with gain of essential properties. Experimental, stress or infection-related deregulation may change B cell fate specification, commitment or population dynamics, and consequently the production rate of mature populations.
More Related Videos
Related Concept Videos
Hematopoiesis
Lineage Commitment
Differentiation of Common Myeloid Progenitor Cells
Production of Formed Elements
Most HSCs commit to...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response

