Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers.

Daniel Cohn1, Gilad Lando, Alejandro Sosnik

  • 1The Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel. danielc@@vms.huji.ac.il

Biomaterials
|November 29, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoparticle-in-microparticle oral delivery system based on drug-loaded polymeric micelles.

Chemical communications (Cambridge, England)·2026
Same author

Exploring the therapeutic potential of cannabidiol in soft tissue wound healing: Delivery strategies and anti-inflammatory pathways.

Acta pharmaceutica Sinica. B·2026
Same author

Nose-to-brain administration of cannabidiol-loaded polymeric micelles improves the core behavioral symptoms of autism spectrum disorder.

Bioactive materials·2026
Same author

A Personalized, 3D Printed Polymeric Device for the Prevention of Post-Myocardial Infarction Cardiac Remodeling.

Advanced healthcare materials·2026
Same author

Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual-Stage Morphing and Drug Release.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Natural Powerhouse Duo: Hierarchical Levan Hydrogels with Nanoencapsulated Cannabidiol as Local Delivery Systems.

Pharmaceutical research·2025
Same journal

Cationic nanotrap curbs UVB-induced cutaneous photodamage via exosomal cfNA capture.

Biomaterials·2026
Same journal

A protein-initiated polymerization cascade enables a self-eliminating powder tissue adhesive for diabetic ulcer repair.

Biomaterials·2026
Same journal

Oral colon-targeted micro-nano formulation engineered in microfluid for synergistic therapy of inflammatory bowel disease.

Biomaterials·2026
Same journal

Manganese@Gold cluster-coordinated covalent organic frameworks-based artificial metalloenzymes with cascade biocatalysis and amplified systemic stimulation to combat malignant tumor metastasis.

Biomaterials·2026
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
See all related articles

New biodegradable thermo-responsive polymers were developed with tunable properties. These poly(ether ester urethane)s offer controlled viscosity and degradation rates for enhanced applications.

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Thermo-responsive polymers are crucial for advanced applications.
  • Developing biodegradable polymers with tailored rheological properties remains a challenge.

Purpose of the Study:

  • To synthesize and characterize novel biodegradable thermo-responsive poly(ether ester urethane)s.
  • To investigate the influence of oligo(ester) blocks on rheological behavior and degradation.

Main Methods:

  • A two-step synthesis involving PEO-PPO-PEO triblock end-capping with oligo(ester)s (LA or CL) followed by chain extension.
  • Rheological measurements (viscosity vs. temperature) and degradation studies (viscosity and molecular weight over time).

Main Results:

Related Experiment Videos

  • Gelation temperature and viscosity at 37°C were modulated by the length and type of oligo(ester) blocks.
  • Increased lactoyl unit length led to higher gelation temperatures but reduced viscosity at body temperature.
  • Degradation rates were tunable based on the oligo(ester) composition.

Conclusions:

  • The developed poly(ether ester urethane)s exhibit tunable thermo-responsive and degradation characteristics.
  • These materials offer potential for applications requiring controlled viscosity and biodegradability.
  • The synthetic strategy allows for precise tailoring of polymer properties.