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Published on: February 10, 2011
Guidelines for the control of glycopeptide-resistant enterococci in hospitals
B D Cookson1, M B Macrae, S P Barrett
1Laboratory of Healthcare Associated Infection, Specialist and Reference Microbiology Division, Health Protection Agency, London, UK.
Abstract:
The increase since the mid 1980s in glycopeptide resistant enterococci (GRE) raised concerns about the limited options for antimicrobial therapy, the implications for ever-increasing numbers of immunocompromised hospitalised patients, and fuelled fears, now realised, for the transfer of glycopeptide resistance to more pathogenic bacteria, such as Staphylococcus aureus. These issues underlined the need for guidelines for the emergence and control of GRE in the hospital setting. This Hospital Infection Society (HIS) and Infection Control Nurses Association (ICNA) working party report reviews the literature relating to GRE prevention and control. It provides guidance on microbiological investigation, treatment and management, including antimicrobial prescribing and infection control measures. Evidence identified to support recommendations has been categorized. A risk assessment approach is recommended and areas for research and development identified.
Insights
Glycopeptide-resistant enterococci (GRE) pose a significant threat to hospital patients, necessitating updated guidelines for prevention and control. This report offers recommendations for managing GRE, including infection control and antimicrobial prescribing strategies.
Area of Science:
- Infectious Diseases
- Microbiology
- Hospital Epidemiology
Background:
- Rising incidence of glycopeptide-resistant enterococci (GRE) since the mid-1980s.
- Concerns regarding limited antimicrobial therapy options and the increasing population of immunocompromised patients.
- Fears of resistance transfer to other pathogens like Staphylococcus aureus have been realized.
Framework:
- Development of guidelines for GRE emergence and control in hospitals.
- Literature review on GRE prevention and control strategies.
- Evidence categorization to support recommendations.
Implementation:
- Guidance on microbiological investigation, treatment, and management of GRE.
- Recommendations for antimicrobial prescribing practices.
- Infection control measures to limit GRE transmission.
Implications:
- Need for a risk assessment approach to manage GRE.
- Identified areas for future research and development in GRE control.
- Mitigation of risks associated with GRE in healthcare settings.
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