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Biodegradable microparticulate system of captopril
P M Dandagi1, V S Mastiholimath, M B Patil
1Department of Pharmaceutics, K.L.E.S's College of Pharmacy, JNMC Campus Nehru Nagar, Belgaum 590010, Karnataka, India. pmdandagi@yahoo.com
International Journal of Pharmaceutics
|November 29, 2005
Summary
Researchers developed bovine serum albumin (BSA) microparticles loaded with captopril for targeted drug delivery. These stable microparticles demonstrated controlled release and preferential organ targeting, showing promise for therapeutic applications.
Area of Science:
- Biomaterials Science
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Albumin microparticles are increasingly utilized in diagnostics and therapeutics.
- Over 100 agents and drugs are currently incorporated into albumin microparticles.
- Bovine serum albumin (BSA) is a common polymer for microparticle formulation.
Purpose of the Study:
- To prepare captopril-loaded BSA microparticles using an emulsification-heat stabilization technique.
- To evaluate the drug loading, particle size, in vitro release, in vivo distribution, and stability of these microparticles.
- To assess the potential of BSA microparticles for targeted drug delivery.
Main Methods:
- Emulsification-heat stabilization technique for microparticle preparation.
- Characterization of particle size distribution and drug incorporation efficiency.
- In vitro drug release studies over 24 hours.
- In vivo tissue distribution analysis.
- Stability assessment under various storage conditions.
Main Results:
- Microparticles exhibited a mean diameter between 2-11 microm, with >70% below 5 microm.
- Drug incorporation efficiency ranged from 41-63%.
- Formulations showed slow, controlled release of captopril up to 24 hours.
- In vivo studies indicated preferential targeting to the liver, followed by lungs, kidneys, and spleen.
- Optimal stability was observed for formulations stored at 4°C.
Conclusions:
- Captopril-loaded BSA microparticles were successfully prepared and demonstrated satisfactory organ targeting.
- The developed microparticles exhibit controlled release properties and good stability at 4°C.
- These findings support the potential of BSA microparticles as a viable drug delivery system.