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Giant cell tumor of bone
1Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada. robert.turcotte@muhc.mcgill.ca
The Orthopedic Clinics of North America
|November 29, 2005
Summary
Giant cell tumors are common benign bone tumors. Treatment involves curettage and bone grafting, with good functional outcomes, though local recurrence is common.
Area of Science:
- Orthopedic Oncology
- Bone Pathology
Background:
- Giant cell tumor (GCT) is a common benign bone neoplasm.
- GCTs characteristically occur at the epiphyses of long bones.
- These tumors exhibit a notable propensity for local recurrence and rare pulmonary metastasis.
Purpose of the Study:
- To summarize the key features of giant cell tumors.
- To outline current preferred treatment strategies.
- To address the ongoing debate regarding adjuvant therapies.
Main Methods:
- Review of established literature on giant cell tumors.
- Analysis of typical clinical presentation and histopathological findings.
- Evaluation of standard surgical interventions and their outcomes.
Main Results:
- Giant cell tumors are benign but locally aggressive.
- Standard treatment involves extensive curettage and bone defect reconstruction (graft or cement).
- Functional outcomes post-treatment are generally favorable.
Conclusions:
- Giant cell tumors require thorough surgical management.
- The role of local adjuvant treatments remains under discussion.
- Despite recurrence potential, functional results are typically excellent.