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Olanzapine versus propranolol in essential tremor
Yeşim Yetimalar1, Gülümser Irtman, Tülay Kurt
1Department of Neurology, Atatürk Training and Research Hospital Izmir, Alsancak, Izmir, Turkey. yetimalar@hotmail.com
Clinical Neurology and Neurosurgery
|November 29, 2005
Summary
Olanzapine demonstrates significant anti-tremor effects in essential tremor (ET) patients, outperforming propranolol in most parameters. Further trials are needed to confirm olanzapine
Area of Science:
- Neurology
- Pharmacology
Background:
- Essential tremor (ET) is a common neurological disorder.
- Current treatments like propranolol have limitations.
Purpose of the Study:
- To evaluate the anti-tremor efficacy of olanzapine in patients with essential tremor.
- To compare olanzapine with propranolol for essential tremor treatment.
Main Methods:
- A randomized, crossover study involving 38 ET patients.
- Patients received olanzapine (20 mg/day) and propranolol (120 mg/day).
- Evaluations included tremor rating and self-reported disability scales.
Main Results:
- Both olanzapine and propranolol improved essential tremor parameters.
- Olanzapine showed significant improvement in most tremor parameters compared to propranolol.
- Hygiene-related tremor parameters were an exception in olanzapine's superior efficacy.
Conclusions:
- Olanzapine may be an effective treatment for essential tremor.
- Further clinical trials are necessary to establish olanzapine's efficacy in ET patients.